Investigating the lung using time-resolved diffuse optics

We have addressed the challenge of investigating the lung using diffuse optics along four different directions, namely: 1) broadband time-domain diffuse optics (TD-DO) in the 600-1100 nm range to derive the mean chest optical properties; 2) Monte Carlo simulations to investigate the depth-sensitivity of TD-DO measurements assuming a layered structure of the chest; 3) single-wavelength TD-DO using a high power pulsed laser on 5 healthy volunteers on a dynamic protocol; 4) single-wavelength TD-DO measurements using a novel large area Silicon Photomultiplier (SIPM) detector module permitting acquisitions at 12 cm source-detector distance.