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The power of drawing as an effective tool for communicating ideas and to represent reality is a well-known topic. However, drawing has shown a much greater potential for knowledge creation, as it can be purposefully used to link and connect ideas and aspects taken from reality, and according to some Scholars it is at the core of the scientific revolution itself. Recent advancements in digital technologies are further increasing the relevance of drawing as a means to create knowledge, especially as regards the purposeful interplay of humans and machines in devising hypotheses and in testing them across disciplines and data types. Are we at the surge of a new scientific paradigm?