A particularly mild and efficient one-pot synthesis of N-substituted benzimidazole derivatives was developed. 2-Fluoro-5-nitrophenylisocyanide reacts with a diverse set of primary amines to afford the respective products in moderate to very good yield (35-95%; 20 examples).

Facile Synthesis of N-Substituted Benzimidazoles

Rossetti A.;
2016-01-01

Abstract

A particularly mild and efficient one-pot synthesis of N-substituted benzimidazole derivatives was developed. 2-Fluoro-5-nitrophenylisocyanide reacts with a diverse set of primary amines to afford the respective products in moderate to very good yield (35-95%; 20 examples).
2016
benzimidazole
isocyanides
nucleophilic aromatic substitution
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1202722
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