In this study, a new in-vitro test bench of the bidirectional superior cavo-pulmonary connection (BCPC), which can mimic realistic conditions, was developed to provide the physician with a platform onto which to test surgical procedures outcomes by acquiring local measurements of the relevant hemodynamic quantities. Using values of resistances and compliance from literature data, a simplified lumped parameters model was designed to fit patients from 2 to 5 years. The mock loop circulation developed in this work was validated by using the in-vivo catheterization data from 20 patients. All the parameters were first set to obtain physiological condition. Then four different dysfunctions were mimicked: diastolic dysfunction, systolic dysfunction, cavo-pulmonary intrinsic failure and a complex mix of these failures. The measured pressure and flow rate showed an excellent correlation with the clinical catheterization data acquired in BCPC. This new in-vitro test bench can be a handy tool capable of providing better insight on how to treat these patients and which devices to employ in different clinical scenarios.
Unassisted in-vitro simulation of superior cavo pulmonary shunt for evaluation of pathophysiological issue
F. De Gaetano;M. L. Costantino
2020-01-01
Abstract
In this study, a new in-vitro test bench of the bidirectional superior cavo-pulmonary connection (BCPC), which can mimic realistic conditions, was developed to provide the physician with a platform onto which to test surgical procedures outcomes by acquiring local measurements of the relevant hemodynamic quantities. Using values of resistances and compliance from literature data, a simplified lumped parameters model was designed to fit patients from 2 to 5 years. The mock loop circulation developed in this work was validated by using the in-vivo catheterization data from 20 patients. All the parameters were first set to obtain physiological condition. Then four different dysfunctions were mimicked: diastolic dysfunction, systolic dysfunction, cavo-pulmonary intrinsic failure and a complex mix of these failures. The measured pressure and flow rate showed an excellent correlation with the clinical catheterization data acquired in BCPC. This new in-vitro test bench can be a handy tool capable of providing better insight on how to treat these patients and which devices to employ in different clinical scenarios.File | Dimensione | Formato | |
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