In this study, a new in-vitro test bench of the bidirectional superior cavo-pulmonary connection (BCPC), which can mimic realistic conditions, was developed to provide the physician with a platform onto which to test surgical procedures outcomes by acquiring local measurements of the relevant hemodynamic quantities. Using values of resistances and compliance from literature data, a simplified lumped parameters model was designed to fit patients from 2 to 5 years. The mock loop circulation developed in this work was validated by using the in-vivo catheterization data from 20 patients. All the parameters were first set to obtain physiological condition. Then four different dysfunctions were mimicked: diastolic dysfunction, systolic dysfunction, cavo-pulmonary intrinsic failure and a complex mix of these failures. The measured pressure and flow rate showed an excellent correlation with the clinical catheterization data acquired in BCPC. This new in-vitro test bench can be a handy tool capable of providing better insight on how to treat these patients and which devices to employ in different clinical scenarios.

Unassisted in-vitro simulation of superior cavo pulmonary shunt for evaluation of pathophysiological issue

F. De Gaetano;M. L. Costantino
2020-01-01

Abstract

In this study, a new in-vitro test bench of the bidirectional superior cavo-pulmonary connection (BCPC), which can mimic realistic conditions, was developed to provide the physician with a platform onto which to test surgical procedures outcomes by acquiring local measurements of the relevant hemodynamic quantities. Using values of resistances and compliance from literature data, a simplified lumped parameters model was designed to fit patients from 2 to 5 years. The mock loop circulation developed in this work was validated by using the in-vivo catheterization data from 20 patients. All the parameters were first set to obtain physiological condition. Then four different dysfunctions were mimicked: diastolic dysfunction, systolic dysfunction, cavo-pulmonary intrinsic failure and a complex mix of these failures. The measured pressure and flow rate showed an excellent correlation with the clinical catheterization data acquired in BCPC. This new in-vitro test bench can be a handy tool capable of providing better insight on how to treat these patients and which devices to employ in different clinical scenarios.
2020
Seventh National Congress of Bioengineering Proceeding
Bidirectional superior cavo pulmonary connection, in-vitro test bench, paediatric circulation, TCPC
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1176281
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