The use of technologies still under development for the upgrade of our multi-wavelength time-resolved optical mammograph, such as silicon photomultipliers and a Time-to-Digital Converter (TDC), highlighted the crucial need for a thorough and progressive instrument characterization: from extensive laboratory tests on phantoms to in vivo measurements. Despite satisfying results on phantoms, in vivo tests urged a significant instrumental change to obtain high-quality breast scans. The setup was upgraded with the adoption of a just-released high-throughput TDC and now grants much wider scan area, better day-by-day reproducibility, and improved signal quality. These results point out the importance of in vivo performance assessment as a general approach for instrument characterization, not limited only to our optical mammograph. After the successful outcomes of the preliminary tests, a clinical study on neoadjuvant chemotherapy monitoring is now ongoing at the San Raffaele Hospital, Milan.

High-throughput multi-wavelength time-resolved optical mammograph: importance of in vivo performance assessment

Maffeis, Giulia;Ferocino, Edoardo;Dalla Mora, Alberto;Cubeddu, Rinaldo;Pifferi, Antonio;Taroni, Paola
2021

Abstract

The use of technologies still under development for the upgrade of our multi-wavelength time-resolved optical mammograph, such as silicon photomultipliers and a Time-to-Digital Converter (TDC), highlighted the crucial need for a thorough and progressive instrument characterization: from extensive laboratory tests on phantoms to in vivo measurements. Despite satisfying results on phantoms, in vivo tests urged a significant instrumental change to obtain high-quality breast scans. The setup was upgraded with the adoption of a just-released high-throughput TDC and now grants much wider scan area, better day-by-day reproducibility, and improved signal quality. These results point out the importance of in vivo performance assessment as a general approach for instrument characterization, not limited only to our optical mammograph. After the successful outcomes of the preliminary tests, a clinical study on neoadjuvant chemotherapy monitoring is now ongoing at the San Raffaele Hospital, Milan.
Optical Tomography and Spectroscopy of Tissue XIV
9781510641136
9781510641143
optical mammography
in vivo measurements
performance assessment
instrument validation
Time-to-Digital Converter
diffuse optics
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/1175510
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