Background: Patient-specific models promises to support the surgical decision-making process, particularly in adolescent idiopathic scoliosis. The present computational biomechanical study investigates how specific instrumentation parameters impact 3D deformity correction in thoracic scoliosis. Methods: 1080 instrumentation simulations of a representative patient were run. The independent instrumentation parameters were: screw pattern, upper and lower instrumented vertebrae, rod curvature and rod stiffness. ANOVA and correlation analyses analyzed how the instrumentation parameters influenced the 3D correction. Findings: Coronal plane correction was affected by the lower instrumented vertebra and rod stiffness (explaining 84% and 11%, respectively, of its overall variance). The sagittal profile was controlled by rod curvature and the upper vertebra (56% and 36%). The transverse plane vertebral rotation was influenced by lower, upper instrumented vertebra and screw pattern (35%, 32% and 19%). The Cobb angle correction was strongly correlated with the number of fused vertebrae, particularly when grouped by the upper instrumented vertebra (r = −0.91) and rod stiffness (r = −0.73). Thoracic kyphosis was strongly correlated with the number of fused vertebrae grouped by rod curvature (r = 0.84). Apical vertebral rotation was moderately correlated with the number of fused vertebrae grouped by upper/lower instrumented vertebra (r = 0.55/0.58), although variations were minimal. Interpretation: Instrumenting the last vertebra touching the central sacral vertical line improves 3D correction. A trade-off between a more cranial vs. caudal upper instrumented vertebra, respectively beneficial for coronal/sagittal vs. transverse plane correction, is required. High rod stiffness, differential rod contouring, and screw pattern were effective for coronal correction, thoracic kyphosis, and axial vertebral derotation, respectively.

How do spine instrumentation parameters influence the 3D correction of thoracic adolescent idiopathic scoliosis? A patient-specific biomechanical study

La Barbera L.;
2021

Abstract

Background: Patient-specific models promises to support the surgical decision-making process, particularly in adolescent idiopathic scoliosis. The present computational biomechanical study investigates how specific instrumentation parameters impact 3D deformity correction in thoracic scoliosis. Methods: 1080 instrumentation simulations of a representative patient were run. The independent instrumentation parameters were: screw pattern, upper and lower instrumented vertebrae, rod curvature and rod stiffness. ANOVA and correlation analyses analyzed how the instrumentation parameters influenced the 3D correction. Findings: Coronal plane correction was affected by the lower instrumented vertebra and rod stiffness (explaining 84% and 11%, respectively, of its overall variance). The sagittal profile was controlled by rod curvature and the upper vertebra (56% and 36%). The transverse plane vertebral rotation was influenced by lower, upper instrumented vertebra and screw pattern (35%, 32% and 19%). The Cobb angle correction was strongly correlated with the number of fused vertebrae, particularly when grouped by the upper instrumented vertebra (r = −0.91) and rod stiffness (r = −0.73). Thoracic kyphosis was strongly correlated with the number of fused vertebrae grouped by rod curvature (r = 0.84). Apical vertebral rotation was moderately correlated with the number of fused vertebrae grouped by upper/lower instrumented vertebra (r = 0.55/0.58), although variations were minimal. Interpretation: Instrumenting the last vertebra touching the central sacral vertical line improves 3D correction. A trade-off between a more cranial vs. caudal upper instrumented vertebra, respectively beneficial for coronal/sagittal vs. transverse plane correction, is required. High rod stiffness, differential rod contouring, and screw pattern were effective for coronal correction, thoracic kyphosis, and axial vertebral derotation, respectively.
CLINICAL BIOMECHANICS
Adolescent idiopathic scoliosis (AIS)
Deformity correction
Implant density
Rod contour
Screw pattern
Spine biomechanics
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/1174874
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