The aim of this work is to evaluate the effects of compliance mismatch on vascular prosthesis failures. For this reason, we carried out a preliminary in vitro characterization of rat vessels and of compliance-tuned grafts. After this first experimental assessment, synthetic grafts are being implanted in vivo in order to evaluate the effects of compliance-matching and compliance-mismatching on the outcome of grafting. In parallel to the implant in the animal model, in silico characterization of graft-vessel interactions is performed, whose outputs (wall stresses and shear stresses) will be correlated with the outcomes of in vivo experiments in terms of vessel’s response.
Development of a compliance-matching biohybrid vascular graft through an integrated approach
Pederzani E.;Caimi A.;Votta E.;Fiore G. B.;Soncini M.;Redaelli A
2020-01-01
Abstract
The aim of this work is to evaluate the effects of compliance mismatch on vascular prosthesis failures. For this reason, we carried out a preliminary in vitro characterization of rat vessels and of compliance-tuned grafts. After this first experimental assessment, synthetic grafts are being implanted in vivo in order to evaluate the effects of compliance-matching and compliance-mismatching on the outcome of grafting. In parallel to the implant in the animal model, in silico characterization of graft-vessel interactions is performed, whose outputs (wall stresses and shear stresses) will be correlated with the outcomes of in vivo experiments in terms of vessel’s response.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
