Skull-base chordomas (SBC) are rare tumours with unfavourable outcomes, even when undergoing advanced treatments such as carbon-ion radiotherapy (CIRT). By retrospectively analysing imaging (MRI, CT), treatment (dose maps) and clinical information available before treatment, the potential use of radiomics and dosiomics for risk modelling targeting SBC treated with CIRT was explored. Despite the small sample size, dosiomic features appear to be promising factors related to local control in SBC, with worse outcomes being associated to higher dose heterogeneity. Risk models exploiting all sources of information showed slightly inferior but good performance, suggesting that multi-parametric approaches are worth being pursued for patient risk stratification. This study is put forward as groundwork for radiomic analyses targeting SBC in CIRT.

Radiomics and Dosiomics for Predicting Local Control After Carbon-Ion Radiotherapy in Skull-Base Chordoma

Buizza, Giulia;Paganelli, Chiara;Baroni, Guido
2021-01-01

Abstract

Skull-base chordomas (SBC) are rare tumours with unfavourable outcomes, even when undergoing advanced treatments such as carbon-ion radiotherapy (CIRT). By retrospectively analysing imaging (MRI, CT), treatment (dose maps) and clinical information available before treatment, the potential use of radiomics and dosiomics for risk modelling targeting SBC treated with CIRT was explored. Despite the small sample size, dosiomic features appear to be promising factors related to local control in SBC, with worse outcomes being associated to higher dose heterogeneity. Risk models exploiting all sources of information showed slightly inferior but good performance, suggesting that multi-parametric approaches are worth being pursued for patient risk stratification. This study is put forward as groundwork for radiomic analyses targeting SBC in CIRT.
2021
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1158586
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 22
social impact