An airway mucus model is proposed thus serving as an in vitro screening tool with the aim to reduce the number of noneffective drugs reaching the preclinical trials. The engineered mucus model is an easy-to-use and easy-to-produce tool that can be easily coupled to state-of-art diffusion models and it is compatible with high throughput analysis. This platform will serve as the basis to implement the complexity of the model in terms of components, also including the effect of bacteria

Hydrogel-based platforms to mimic in vivo drug diffusion: A multicenter research

Briatico Vangosa, Francesco;Pacheco, Daniela;Petrini, Paola
2020-01-01

Abstract

An airway mucus model is proposed thus serving as an in vitro screening tool with the aim to reduce the number of noneffective drugs reaching the preclinical trials. The engineered mucus model is an easy-to-use and easy-to-produce tool that can be easily coupled to state-of-art diffusion models and it is compatible with high throughput analysis. This platform will serve as the basis to implement the complexity of the model in terms of components, also including the effect of bacteria
In vitro models, diffusion profiles, hydrogels, mucins, permeability
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1155992
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