Perfusion cell culture processes for biopharmaceuticals: Process Development, Design, and Scale-up

Master the design and operation of perfusion cell cultures with this authoritative reference. Discover the current state of the art in the design and operation of continuous bioreactors, with emphasis on mammalian cell cultures for producing therapeutic proteins. Topics include the current market for recombinant therapeutic proteins, current industry challenges, and the potential contribution of continuous manufacturing. The volume provides coverage of every step of process development and reactor operation, including smallscale screening to lab-scale and scale-up to manufacturing scale. Illustrated through real-life case studies, this is a perfect resource for groups active in the cell culture field, as well as graduate students in areas such as chemical engineering, biotechnology, chemistry, and biology, and to those in the pharmaceutical industry, particularly biopharma, biotechnology, and food or agro industry.