Monofunctional supramolecular Pt(II) complexes: Synthesis, single crystal structure, anticancer activity, E. coli growth retardation and DNA interaction study

Two new monofunctional mono-metallic trans-Pt(II)(salicylaldimine)(pyridine)·BF 4 (C1) and supramolecular dimetallic trans-(Pt(II)(salicylaldimine)) 2 (4,4-bipyridine)·2BF 4 (C2) complexes were designed and synthesized through ancillary chloride ligand exchange strategy and structurally characterized by spectroscopic, spectrophotometric and single crystal X-ray analyses. The solid-state structure analyses revealed interactions between the coordination planes, inter-molecular H-bonding, bonding in the ligand hydrogen and BF 4 anions and supramolecular interactions with solvent molecules in crystal packing. The in vitro anticancer effect of these complexes was investigated in breast (MCF-7) and liver (HepG2) cancer cells. Both these complexes showed significant anticancer effect comparable to cisplatin. Similarly, the effect of these complexes on Escherichia coli (E. coli) growth retardation was also analyzed and the results revealed stronger growth retardation effect and elongated morphology of bacterial cells in similar fashion as observed for cisplatin. The DNA interaction of C1 and C2 was investigated by gel electrophoresis using pET28 as target DNA. These complexes retarded migration of DNA across the gel showing their interaction with DNA.