Osteoarthritis (OA) is the most common musculoskeletal disease worldwide and yet an effective therapy is still absent. Associated with cartilage degeneration, OA is recognized as a complex whole joint disease [1], making in vitro modelling particularly cumbersome. Available in vitro models are, however, largely 2D based and not representative of the joint environment. As a result, failure meets attempts at translating promising pre-clinical OA disease modifying drugs (DMOADs) into clinical success. This shortcoming calls for more efficient pre-clinical tools, able to reliably predict DMOA drugs’ efficacy in vivo. In this study we developed a microscale platform providing 3D microconstructs with mechanical compression. The device was used in generating an OA cartilage-on-chip model, and DMOADs screening capability assessed.

Cartilage-on-chip model: triggering osteoarthritis traits through mechanical compression

Mainardi A;Occhetta P;Votta E;Rasponi M
2018

Abstract

Osteoarthritis (OA) is the most common musculoskeletal disease worldwide and yet an effective therapy is still absent. Associated with cartilage degeneration, OA is recognized as a complex whole joint disease [1], making in vitro modelling particularly cumbersome. Available in vitro models are, however, largely 2D based and not representative of the joint environment. As a result, failure meets attempts at translating promising pre-clinical OA disease modifying drugs (DMOADs) into clinical success. This shortcoming calls for more efficient pre-clinical tools, able to reliably predict DMOA drugs’ efficacy in vivo. In this study we developed a microscale platform providing 3D microconstructs with mechanical compression. The device was used in generating an OA cartilage-on-chip model, and DMOADs screening capability assessed.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1121341
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