Herein, we report the crystal structures of the antimicrobial agent diiodomethyl-p-tolylsulfone and of three halogen bonded co-crystals demonstrating that the bioactive moiety -SO2CHI2 can function as a quite effective halogen bond based motif in the solid state and in solution, namely demonstrating that α-iodosulfones may become a new entry in the quite small group of alkyl-iodides functioning as reliable halogen bond-donors.

The diiodomethyl-sulfonyl moiety: an unexplored halogen bond-donor motif

Dichiarante, Valentina;Metrangolo, Pierangelo;Pilati, Tullio;Resnati, Giuseppe;Terraneo, Giancarlo;Ursini, Maurizio
2019

Abstract

Herein, we report the crystal structures of the antimicrobial agent diiodomethyl-p-tolylsulfone and of three halogen bonded co-crystals demonstrating that the bioactive moiety -SO2CHI2 can function as a quite effective halogen bond based motif in the solid state and in solution, namely demonstrating that α-iodosulfones may become a new entry in the quite small group of alkyl-iodides functioning as reliable halogen bond-donors.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1087856
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