Herein, we report the crystal structures of the antimicrobial agent diiodomethyl-p-tolylsulfone and of three halogen bonded co-crystals demonstrating that the bioactive moiety -SO2CHI2 can function as a quite effective halogen bond based motif in the solid state and in solution, namely demonstrating that α-iodosulfones may become a new entry in the quite small group of alkyl-iodides functioning as reliable halogen bond-donors.
The diiodomethyl-sulfonyl moiety: an unexplored halogen bond-donor motif
Dichiarante, Valentina;Metrangolo, Pierangelo;Pilati, Tullio;Resnati, Giuseppe;Terraneo, Giancarlo;Ursini, Maurizio
2019-01-01
Abstract
Herein, we report the crystal structures of the antimicrobial agent diiodomethyl-p-tolylsulfone and of three halogen bonded co-crystals demonstrating that the bioactive moiety -SO2CHI2 can function as a quite effective halogen bond based motif in the solid state and in solution, namely demonstrating that α-iodosulfones may become a new entry in the quite small group of alkyl-iodides functioning as reliable halogen bond-donors.File in questo prodotto:
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