The experimental characterization of a SiPM-based 10-module SPECT gamma imager suitable for insertion and operation inside unmodified MR scanners for simultaneous (and potentially multi-tracer) preclinical imaging is presented. The design challenges, here fulfilled, such as compactness while granting proper cooling, mutual compatibility and resilience to high (3-7 T) magnetic fields inside the bore, suitable energetic (better than 14% at 140 keV) and spatial resolution (better than 1 mm) are discussed. The carefully optimized detection module, featuring a 5 imes5 cm^2 CsI(Tl) scintillator coupled to arrays of SiPM conditioned by a 36-channel ASIC, and the digital daisy chain infrastructure are the basis for the realization of a larger (20-module ring) clinical insert. Moreover, planar image reconstruction based on advanced statistical approaches such as maximum likelihood and iteratively estimated light response function is reported.
Experimental Validation of a Preclinical SPECT/MR Insert
Carminati, M.;Occhipinti, M.;Montagnani, G. L.;Fiorini, C.
2017-01-01
Abstract
The experimental characterization of a SiPM-based 10-module SPECT gamma imager suitable for insertion and operation inside unmodified MR scanners for simultaneous (and potentially multi-tracer) preclinical imaging is presented. The design challenges, here fulfilled, such as compactness while granting proper cooling, mutual compatibility and resilience to high (3-7 T) magnetic fields inside the bore, suitable energetic (better than 14% at 140 keV) and spatial resolution (better than 1 mm) are discussed. The carefully optimized detection module, featuring a 5 imes5 cm^2 CsI(Tl) scintillator coupled to arrays of SiPM conditioned by a 36-channel ASIC, and the digital daisy chain infrastructure are the basis for the realization of a larger (20-module ring) clinical insert. Moreover, planar image reconstruction based on advanced statistical approaches such as maximum likelihood and iteratively estimated light response function is reported.File | Dimensione | Formato | |
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