Fluorescent poly(ϵ-caprolactone)-based nanoparticles (NPs) have been synthesized and successfully loaded with a titanium organometallic compound as a mimic of a water-insoluble drug. The nature of this nanovector enabled us to combine the quantification of the metal in tissues after systemic administration in healthy immunocompetent mice by inductively coupled plasma mass spectroscopy (ICP-MS) followed by the visualization of NPs in organ sections by confocal microscopy. This innovative method of nanodrug screening has enabled us to elucidate the crucial parameters of their kinetics. The organometallic compound is a good mimic of most anticancer drugs, and this approach is an interesting starting point to design the relevance of a broad range of nanoformulations in terms of safety and targeted delivery of the cargoes.

Biocompatible Polymer Nanoformulation to Improve the Release and Safety of a Drug Mimic Molecule Detectable via ICP-MS

mattia Sponchioni;massimo Morbidelli;davide Moscatelli
2017-01-01

Abstract

Fluorescent poly(ϵ-caprolactone)-based nanoparticles (NPs) have been synthesized and successfully loaded with a titanium organometallic compound as a mimic of a water-insoluble drug. The nature of this nanovector enabled us to combine the quantification of the metal in tissues after systemic administration in healthy immunocompetent mice by inductively coupled plasma mass spectroscopy (ICP-MS) followed by the visualization of NPs in organ sections by confocal microscopy. This innovative method of nanodrug screening has enabled us to elucidate the crucial parameters of their kinetics. The organometallic compound is a good mimic of most anticancer drugs, and this approach is an interesting starting point to design the relevance of a broad range of nanoformulations in terms of safety and targeted delivery of the cargoes.
biodistribution; drug delivery; drug development; ICP-MS; nanoparticle; titanium; Animals; Antineoplastic Agents; Biocompatible Materials; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Male; Mice; Microscopy, Electron, Transmission; Nanoparticles; Organometallic Compounds; Polyesters; Polymers; Titanium; Molecular Medicine; 3003; Drug Discovery3003 Pharmaceutical Science
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1066224
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