The application of a number of chiral bispidine-based ligands in the copper-catalyzed enantioselective Henry reaction is here reported. The results showed good conversion rates and low to moderate enantiomeric ratios, depending on the substituents on the bispidine core. The enantioselectivities of selected ligands were rationalized on the basis of single-crystal X-ray analyses, NMR studies and computational tools.

Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(ii)-catalyzed asymmetric Henry reaction

Arianna Rossetti;Greta Colombo Dugoni;Alessandro Sacchetti
2018

Abstract

The application of a number of chiral bispidine-based ligands in the copper-catalyzed enantioselective Henry reaction is here reported. The results showed good conversion rates and low to moderate enantiomeric ratios, depending on the substituents on the bispidine core. The enantioselectivities of selected ligands were rationalized on the basis of single-crystal X-ray analyses, NMR studies and computational tools.
File in questo prodotto:
File Dimensione Formato  
c8nj01930d.pdf

Accesso riservato

: Publisher’s version
Dimensione 2.64 MB
Formato Adobe PDF
2.64 MB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/1066026
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 9
social impact