The aim of this work is to develop a computational model of the interplay between microcirculation and interstitial flow. Such phenomena are at the basis of the exchange of nutrients, wastes and pharmacological agents between the cardiovascular system and the organs. They are particularly interesting for the study of effective therapies to treat vascularized tumors. We develop a model applicable at the microscopic scale, where the capillaries and the interstitial volume can be described as independent structures able to propagate flow and chemicals. Different solution techniques of the problem derived from the proposed model are analyzed in this work.
A mixed finite element method for modeling the fluid exchange between microcirculation and tissue interstitium
CERRONI, DANIELE;LAURINO, FEDERICA;Formaggia, Luca;Scotti, Anna;Zunino, Paolo
2018-01-01
Abstract
The aim of this work is to develop a computational model of the interplay between microcirculation and interstitial flow. Such phenomena are at the basis of the exchange of nutrients, wastes and pharmacological agents between the cardiovascular system and the organs. They are particularly interesting for the study of effective therapies to treat vascularized tumors. We develop a model applicable at the microscopic scale, where the capillaries and the interstitial volume can be described as independent structures able to propagate flow and chemicals. Different solution techniques of the problem derived from the proposed model are analyzed in this work.| File | Dimensione | Formato | |
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