A periodic monitoring of the adipose tissue functions due to interventions, such as calorie restriction and bariatric surgery, or pathophysiological processes, has an increasing relevance in clinical diagnostics. Diffuse Optical Spectroscopy (DOS) is a valuable non-invasive tool that can be used in that direction. In this work, we present a pilot study based on Time Domain Broadband Diffuse Optical Spectroscopy (TD DOS) to characterize in vivo the subcutaneous fat tissue in the abdominal region. A first of its kind, portable TD DOS instrumentation, already enrolled in clinical studies, was used. Three healthy male volunteers were considered. Three source-detector separation distances (1, 2, and 3 cm) were used over the broad wavelength range of 600-1100 nm. The analysis was performed using a method based on a heterogeneous model to account for the multi-layered nature of the subcutaneous adipose tissue, and to obtain the optical properties specific to this fat localization. Inter-subject variation of tissue composition data was observed.

Multidistance time domain diffuse optical spectroscopy in the assessment of abdominal fat heterogeneity

LANKA, SRI RAMA PRANAV KUMAR;Konugolu Venkata Sekar, S.;Taroni, P.;Cubeddu, R.;Pifferi, A.
2018

Abstract

A periodic monitoring of the adipose tissue functions due to interventions, such as calorie restriction and bariatric surgery, or pathophysiological processes, has an increasing relevance in clinical diagnostics. Diffuse Optical Spectroscopy (DOS) is a valuable non-invasive tool that can be used in that direction. In this work, we present a pilot study based on Time Domain Broadband Diffuse Optical Spectroscopy (TD DOS) to characterize in vivo the subcutaneous fat tissue in the abdominal region. A first of its kind, portable TD DOS instrumentation, already enrolled in clinical studies, was used. Three healthy male volunteers were considered. Three source-detector separation distances (1, 2, and 3 cm) were used over the broad wavelength range of 600-1100 nm. The analysis was performed using a method based on a heterogeneous model to account for the multi-layered nature of the subcutaneous adipose tissue, and to obtain the optical properties specific to this fat localization. Inter-subject variation of tissue composition data was observed.
SPIE Proceedings: Biophotonics: Photonic Solutions for Better Health Care VI
9781510618961
Abdomen; absorption; adipose tissue; diffuse optics; fat; heterogeneous; non-invasive; time domain; Electronic, Optical and Magnetic Materials; Condensed Matter Physics; Computer Science Applications1707 Computer Vision and Pattern Recognition; Applied Mathematics; Electrical and Electronic Engineering
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/1059286
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