A novel total synthesis leading to the carbazole alkaloid carbazomycin G was designed and developed. The outlined synthetic route is composed of twelve synthetic steps including the transformations of the very first simple substrate and intermediates. In order to realize the designed synthesis, in total six new synthetic methods were developed and implemented in the new total synthesis, which afforded target molecule in an overall yield of 8.3%.

Carbazomycin G: Method development and total synthesis

Gambarotti, Cristian;
2018-01-01

Abstract

A novel total synthesis leading to the carbazole alkaloid carbazomycin G was designed and developed. The outlined synthetic route is composed of twelve synthetic steps including the transformations of the very first simple substrate and intermediates. In order to realize the designed synthesis, in total six new synthetic methods were developed and implemented in the new total synthesis, which afforded target molecule in an overall yield of 8.3%.
Synthetic methods, Total synthesis, Cross-coupling, C–H activation, C–N bond formation, Redox reactions
File in questo prodotto:
File Dimensione Formato  
Eur. J. Org. Chem. 2018, 1984–1992.pdf

Accesso riservato

Descrizione: Total Synthesis of Carbazomycin G
: Publisher’s version
Dimensione 6.07 MB
Formato Adobe PDF
6.07 MB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1054488
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact