The research here presented aims to the investigation of the Autonomic Nervous System (ANS) and of the sympatho-vagal balance during sleep-related seizures in patients affected by Focal Cortical Dysplasia (FCD) type II. Heart Rate Variability (HRV) signal was recorded during sleep together with S-EEG (stereo EEG) acquisitions performed for pre-surgical evaluation. The sympatho-vagal balance was estimated in pre-ictal, ictal and post-ictal time, by means of parameters in the time and in the frequency domain. The results here presented are related to 10 epileptic seizures occurring during the same night in one patient. The obtained results testify a significant decrease (p < 0.005) in the RR mean value and standard deviation during the ictal and post-ictal periods in respect to the inter-ictal phase, and a significant decrease (p < 0.001) in the HF(%) power between inter-ictal and post-ictal periods. All these findings are associated to a sympathetic activation and to a vagal drive reduction. A deeper knowledge of the correlations between ANS and epilepsy can lead to better understand the causes of SUDEP (Sudden Unexpected Death in Epilepsy); can contribute to the development of methods for the detection and prediction of epileptic seizures and help to evaluate the effects of vagal nerve stimulation used in those cases in which the patient is not an ideal candidate for surgery.

Measuring autonomic involvement related to seizure onset in Focal Cortical Dysplasia type II

Bianchi, Anna M.;Coelli, Stefania;
2017

Abstract

The research here presented aims to the investigation of the Autonomic Nervous System (ANS) and of the sympatho-vagal balance during sleep-related seizures in patients affected by Focal Cortical Dysplasia (FCD) type II. Heart Rate Variability (HRV) signal was recorded during sleep together with S-EEG (stereo EEG) acquisitions performed for pre-surgical evaluation. The sympatho-vagal balance was estimated in pre-ictal, ictal and post-ictal time, by means of parameters in the time and in the frequency domain. The results here presented are related to 10 epileptic seizures occurring during the same night in one patient. The obtained results testify a significant decrease (p < 0.005) in the RR mean value and standard deviation during the ictal and post-ictal periods in respect to the inter-ictal phase, and a significant decrease (p < 0.001) in the HF(%) power between inter-ictal and post-ictal periods. All these findings are associated to a sympathetic activation and to a vagal drive reduction. A deeper knowledge of the correlations between ANS and epilepsy can lead to better understand the causes of SUDEP (Sudden Unexpected Death in Epilepsy); can contribute to the development of methods for the detection and prediction of epileptic seizures and help to evaluate the effects of vagal nerve stimulation used in those cases in which the patient is not an ideal candidate for surgery.
RTSI 2017 - IEEE 3rd International Forum on Research and Technologies for Society and Industry, Conference Proceedings
9781538639061
Heart rate variability; sleep; stereo-EEG; Computer Networks and Communications; Computer Science Applications1707 Computer Vision and Pattern Recognition; Energy Engineering and Power Technology; Industrial and Manufacturing Engineering; Health (social science); Management of Technology and Innovation; Artificial Intelligence
File in questo prodotto:
File Dimensione Formato  
Bianchi_RTSI_2017.pdf

Accesso riservato

: Publisher’s version
Dimensione 1.04 MB
Formato Adobe PDF
1.04 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/1040061
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 0
social impact