Collagen content was estimated on 109 subjects (53 healthy and 56 with malignant breast lesions) performing time domain 7-wavelength (635-1060 nm) optical mammography. Subjects with higher age-matched collagen content (top 15%) show higher cancer occurrence. Collagen correlates with mammographic density (recognized risk factor for breast cancer). However, top 15% clustering based on percentage mammographic density identifies a different set of patients, potentially indicating collagen as an independent breast cancer risk factor. If confirmed on a wider population, these initial results could have huge impact on personalized diagnostics and health care systems.
Is collagen an independent risk factor for breast cancer?
Taroni, Paola;Paganoni, Anna Maria;Ieva, Francesca;Cubeddu, Rinaldo;Pifferi, Antonio
2016-01-01
Abstract
Collagen content was estimated on 109 subjects (53 healthy and 56 with malignant breast lesions) performing time domain 7-wavelength (635-1060 nm) optical mammography. Subjects with higher age-matched collagen content (top 15%) show higher cancer occurrence. Collagen correlates with mammographic density (recognized risk factor for breast cancer). However, top 15% clustering based on percentage mammographic density identifies a different set of patients, potentially indicating collagen as an independent breast cancer risk factor. If confirmed on a wider population, these initial results could have huge impact on personalized diagnostics and health care systems.File | Dimensione | Formato | |
---|---|---|---|
OSA2016_Collagen&Risk_Abs2.pdf
Open Access dal 01/01/2018
Descrizione: Abstract (3 pagine)
:
Publisher’s version
Dimensione
341.45 kB
Formato
Adobe PDF
|
341.45 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.