The tissue equivalent proportional counter (TEPC) is the most accurate device for measuring the microdosimetric properties of a particle beam, showing to assess the relative biological effectiveness by linking the physical parameters of the radiation field with the corresponding biological response. Nevertheless, no detailed information on the track structure of the impinging particles can be obtained, since the lower operation limit of the common TEPCs is about 0.3 μm. On the other hand, the pattern of particle interactions at the nanometer level, which demonstrated to have a strong correlation with radiation-induced damages to the DNA, is measured directly by only three different nanodosimeters worldwide: practical instruments are not yet available. The gap between microdosimetry and track-nanodosimetry can be filled partially by extending the TEPC response down to the nanometric region. A feasibility study of a novel TEPC designed to simulate tissue-equivalent sites in the nanometric domain was performed. The present paper aims at describing the design, the development and the characterization of this avalanche-confinement TEPC. Irradiations with photons, fast neutrons and low-energy carbon ions demonstrated the capability of this TEPC of measuring in the range 0.3 μm–25 nm.

A novel avalanche-confinement TEPC for microdosimetry at nanometric level

BORTOT, DAVIDE;POLA, ANDREA;GIULINI CASTIGLIONI AGOSTEO, STEFANO LUIGI MARIA;PASQUATO, STEFANO;MAZZUCCONI, DAVIDE;FAZZI, ALBERTO;COLAUTTI, PAOLO;CONTE, VALERIA
2017

Abstract

The tissue equivalent proportional counter (TEPC) is the most accurate device for measuring the microdosimetric properties of a particle beam, showing to assess the relative biological effectiveness by linking the physical parameters of the radiation field with the corresponding biological response. Nevertheless, no detailed information on the track structure of the impinging particles can be obtained, since the lower operation limit of the common TEPCs is about 0.3 μm. On the other hand, the pattern of particle interactions at the nanometer level, which demonstrated to have a strong correlation with radiation-induced damages to the DNA, is measured directly by only three different nanodosimeters worldwide: practical instruments are not yet available. The gap between microdosimetry and track-nanodosimetry can be filled partially by extending the TEPC response down to the nanometric region. A feasibility study of a novel TEPC designed to simulate tissue-equivalent sites in the nanometric domain was performed. The present paper aims at describing the design, the development and the characterization of this avalanche-confinement TEPC. Irradiations with photons, fast neutrons and low-energy carbon ions demonstrated the capability of this TEPC of measuring in the range 0.3 μm–25 nm.
Microdosimetry; Nanodosimetry; Tissue equivalent proportional counter (TEPC); Radiation; Instrumentation
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11311/1032107
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