The in vitro replication of physiological mechanical conditioning through bioreactors plays a crucial role in the development of functional Small-Caliber Tissue-Engineered Blood Vessels. An in silico scaffold-specific model under pulsatile perfusion provided by a bioreactor was implemented using a fluid-structure interaction (FSI) approach for viscoelastic tubular scaffolds (e.g. decellularized swine arteries, DSA). Results of working pressures, circumferential deformations, and wall shear stress on DSA fell within the desired physiological range and indicated the ability of this model to correctly predict the mechanical conditioning acting on the cells-scaffold system. Consequently, the FSI model allowed us to a priori define the stimulation pattern, driving in vitro physiological maturation of scaffolds, especially with viscoelastic properties.

Estimation of the physiological mechanical conditioning in vascular tissue engineering by a predictive fluid-structure interaction approach

Tresoldi, Claudia;Bianchi, Elena;Pellegata, Alessandro Filippo;Dubini, Gabriele;Mantero, Sara
2017-01-01

Abstract

The in vitro replication of physiological mechanical conditioning through bioreactors plays a crucial role in the development of functional Small-Caliber Tissue-Engineered Blood Vessels. An in silico scaffold-specific model under pulsatile perfusion provided by a bioreactor was implemented using a fluid-structure interaction (FSI) approach for viscoelastic tubular scaffolds (e.g. decellularized swine arteries, DSA). Results of working pressures, circumferential deformations, and wall shear stress on DSA fell within the desired physiological range and indicated the ability of this model to correctly predict the mechanical conditioning acting on the cells-scaffold system. Consequently, the FSI model allowed us to a priori define the stimulation pattern, driving in vitro physiological maturation of scaffolds, especially with viscoelastic properties.
2017
Small-caliber vessel tissue engineering
bioreactor
circumferential deformations
fluid-structure interaction model
mechanical conditioning
wall shear stress
Animals
Arteries
Biomechanical Phenomena
Bioreactors
Blood Vessels
Models, Theoretical
Pressure
Stress, Mechanical
Swine
Tissue Engineering
Tissue Scaffolds
Rheology
Small-caliber vessel tissue engineering; bioreactor; circumferential deformations; fluid-structure interaction model; mechanical conditioning; wall shear stress
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1221577
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