The aim of the study was to determine in human patients the effect of lung resection on lung compliance and on pleuro-pulmonary fluid balance. Pre and post-operative values of compliance were measured in anesthetized patients undergoing resection for lung cancer (N=11) through double-lumen bronchial intubation. Lung compliance was measured for 10-12cmH2O increase in alveolar pressure from 5cmH2O PEEP in control and repeated after resection. No air leak was assessed and pleural fluid was collected during hospital stay. A significant negative correlation (r2=0.68) was found between compliance at 10min and resected mass. Based on the pre-operative estimated lung weight, the decrease in compliance following lung resection exceeded by 10-15% that expected from resected mass. Significant negative relationships were found by relating pleural fluid drainage flow to the remaining lung mass and to post-operative lung compliance. Following lung re-expansion, data suggest a causative relationship between the decrease in compliance and the perturbation in pleuro-pulmonary fluid balance.

Effect of lung resection on pleuro-pulmonary mechanics and fluid balance

SALITO, CATERINA;BOVIO, DARIO;ALIVERTI, ANDREA;
2016-01-01

Abstract

The aim of the study was to determine in human patients the effect of lung resection on lung compliance and on pleuro-pulmonary fluid balance. Pre and post-operative values of compliance were measured in anesthetized patients undergoing resection for lung cancer (N=11) through double-lumen bronchial intubation. Lung compliance was measured for 10-12cmH2O increase in alveolar pressure from 5cmH2O PEEP in control and repeated after resection. No air leak was assessed and pleural fluid was collected during hospital stay. A significant negative correlation (r2=0.68) was found between compliance at 10min and resected mass. Based on the pre-operative estimated lung weight, the decrease in compliance following lung resection exceeded by 10-15% that expected from resected mass. Significant negative relationships were found by relating pleural fluid drainage flow to the remaining lung mass and to post-operative lung compliance. Following lung re-expansion, data suggest a causative relationship between the decrease in compliance and the perturbation in pleuro-pulmonary fluid balance.
2016
Aged; Aged, 80 and over; Female; Humans; Lung; Lung Compliance; Lung Neoplasms; Male; Middle Aged; Pleura; Positive-Pressure Respiration; Respiratory Mechanics; Statistics as Topic; Water-Electrolyte Balance; Neuroscience (all); Physiology; Pulmonary and Respiratory Medicine
File in questo prodotto:
File Dimensione Formato  
Salito-RPNB_2016.pdf

Accesso riservato

: Publisher’s version
Dimensione 974.7 kB
Formato Adobe PDF
974.7 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1009979
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact