An efficient multicomponent domino process that works under mild conditions was used for the synthesis of systematically modified neomycin-sugar conjugates. The final aminoglycoside derivatives were tested against methicillin-resistant Staphylococcus aureus, Klebsiella, and E. coli strains, and show activity comparable to the parent antibiotics. Such a strategy can impact multicomponent combinatorial syntheses of diverse biologically active conjugates.

Multicomponent Domino Synthesis and Antibacterial Activity of Neomycin-Sugar Conjugates

SGANAPPA, AURORA;VOLONTERIO, ALESSANDRO
2016

Abstract

An efficient multicomponent domino process that works under mild conditions was used for the synthesis of systematically modified neomycin-sugar conjugates. The final aminoglycoside derivatives were tested against methicillin-resistant Staphylococcus aureus, Klebsiella, and E. coli strains, and show activity comparable to the parent antibiotics. Such a strategy can impact multicomponent combinatorial syntheses of diverse biologically active conjugates.
aminoglycosides; antibiotics; carbodiimides; domino reaction; multicomponent reaction; Catalysis; Organic Chemistry
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11311/1009658
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