The title benzofuranones I [R = H, R1 = H, R2 = H, Me, Ph, C6H3F2-2,4, OPh (II), SMe; R = R2 = H, R1 = Me, CH2CHMe2 (III), OMe; R = H, R1 = OH, R2 = CH2Ph; RR1 = CH:CHCR3:CH [R3 = H, OMe (IV)]] were prepd. in 50-81% yield by condensation of the corresponding 2,3,4-RR1R2C6H2OH with MeCOCO2Et in refluxing CH2Cl2 contg. TiCl4, Zn, and AcOH for 3 h. II-IV showed antiinflammatory activity in vivo
A simple route to benzofuran-2(3H)-ones
CITTERIO, ATTILIO
1985-01-01
Abstract
The title benzofuranones I [R = H, R1 = H, R2 = H, Me, Ph, C6H3F2-2,4, OPh (II), SMe; R = R2 = H, R1 = Me, CH2CHMe2 (III), OMe; R = H, R1 = OH, R2 = CH2Ph; RR1 = CH:CHCR3:CH [R3 = H, OMe (IV)]] were prepd. in 50-81% yield by condensation of the corresponding 2,3,4-RR1R2C6H2OH with MeCOCO2Et in refluxing CH2Cl2 contg. TiCl4, Zn, and AcOH for 3 h. II-IV showed antiinflammatory activity in vivoFile in questo prodotto:
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