As a first crucial stage for production of PMMA scaffolds, this work provides the kinetic and dynamic characterization of the MMA/Ethyl Acetate/AIBN polymerization process. Kinetic parameters are estimated by means of experimental campaigns performed on a dedicated pilot plant (batch reactor). A novel, rigorous mathematical model is developed and implemented in Fortran 90 so as to consider the peculiar characteristics and the new structure of the pilot plant and the batch reactor: actually, the new plant configuration is designed to produce the appropriated PMMA scaffolds for medical application (with very stringent specifications for low toxicity and high biocompatibility). The good agreement between model previsions and experimental results validates the kinetic parameters and the dynamic modeling.
Pilot-plant Simulation, Experimental Campaign and Rigorous Modeling of a Batch MMA Polymerization Reactor for the Fabrication of Bone Tissue
MANENTI, FLAVIO;
2012-01-01
Abstract
As a first crucial stage for production of PMMA scaffolds, this work provides the kinetic and dynamic characterization of the MMA/Ethyl Acetate/AIBN polymerization process. Kinetic parameters are estimated by means of experimental campaigns performed on a dedicated pilot plant (batch reactor). A novel, rigorous mathematical model is developed and implemented in Fortran 90 so as to consider the peculiar characteristics and the new structure of the pilot plant and the batch reactor: actually, the new plant configuration is designed to produce the appropriated PMMA scaffolds for medical application (with very stringent specifications for low toxicity and high biocompatibility). The good agreement between model previsions and experimental results validates the kinetic parameters and the dynamic modeling.File | Dimensione | Formato | |
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