+)-(R)- and (−)-(S)-3,3,3-trifluoro-2-methyl-alanine (1) were synthesized from (+)-(R)-methyl-p-tolyl-sulphoxide (5) and N-alkoxycarbonylimino derivatives 4 of methyl 3,3,3-trifluoropyruvate (3). The absolute configuration was determined by X-ray analyses of two synthetic intermediates (2S,RS)-6a and (2R,RS-6c.
Synthesis of optically pure (R)- and (S)-alpha-trifluoromethyl-alanine
MEILLE, STEFANO VALDO;
1994-01-01
Abstract
+)-(R)- and (−)-(S)-3,3,3-trifluoro-2-methyl-alanine (1) were synthesized from (+)-(R)-methyl-p-tolyl-sulphoxide (5) and N-alkoxycarbonylimino derivatives 4 of methyl 3,3,3-trifluoropyruvate (3). The absolute configuration was determined by X-ray analyses of two synthetic intermediates (2S,RS)-6a and (2R,RS-6c.File in questo prodotto:
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