A series of 2-carboxy-1,4-androstadien-3-one derivatives and their alkyl esters, were prepared by high-yield syntheses. The compounds were structurally identified by physical methods. All these steroids are characterized by a marked antiglucocorticoid activity that proved long-acting in the case of the ester derivatives. 2-Carboxy-11β, 17β-dihydroxy-17-methyl-1,4-androstadien-3-one or roxibolone, and its n-decylester or decylroxibolone, are the most promising derivatives in consideration of their pharmacological properties.
Synthesis of 2-carboxy-11β,17β-dihydroxy-17-methyl-l,4-androstadien-3-one and related compounds
RESNATI, GIUSEPPE;
1984-01-01
Abstract
A series of 2-carboxy-1,4-androstadien-3-one derivatives and their alkyl esters, were prepared by high-yield syntheses. The compounds were structurally identified by physical methods. All these steroids are characterized by a marked antiglucocorticoid activity that proved long-acting in the case of the ester derivatives. 2-Carboxy-11β, 17β-dihydroxy-17-methyl-1,4-androstadien-3-one or roxibolone, and its n-decylester or decylroxibolone, are the most promising derivatives in consideration of their pharmacological properties.File in questo prodotto:
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