The mass spectrometric behavior of some 10β-fluoro-1,4-estradiene-3-oxo steroids under two different ionization conditions (electron inpact and fast atom bombardment) was studied with the aid of mass-analyzed ion kinetic energy spectroscopy. The influence of fluorine in the fragmentation pattern was investigated by comparison with the behavior of 10-methyl analogs. In particular, the presence of fluorine at position 10 seems to reflect the weakening of C(9)C(10) bond. Further, when an acyloxy moiety is present at position 17, the primary ring cleavages typical of steroids become disfavored and fragment ions related to the acyloxy substituents are detected.
Mass spectrometry of some 10β-Fluoro-1,4-estradien-3-oxo steroids
RESNATI, GIUSEPPE;
1994-01-01
Abstract
The mass spectrometric behavior of some 10β-fluoro-1,4-estradiene-3-oxo steroids under two different ionization conditions (electron inpact and fast atom bombardment) was studied with the aid of mass-analyzed ion kinetic energy spectroscopy. The influence of fluorine in the fragmentation pattern was investigated by comparison with the behavior of 10-methyl analogs. In particular, the presence of fluorine at position 10 seems to reflect the weakening of C(9)C(10) bond. Further, when an acyloxy moiety is present at position 17, the primary ring cleavages typical of steroids become disfavored and fragment ions related to the acyloxy substituents are detected.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.