We demonstrate the detection of the Brownian relaxation frequency of 250 nm diameter magnetic beads using a lab-on-chip platform based on current lines for exciting the beads with alternating magnetic fields and highly sensitive magnetic tunnel junction MTJ sensors with a superparamagnetic free layer. The first harmonic out-of-phase component of the MTJ response gives the imaginary part of the magnetic bead susceptibility, which peaks at the Brownian relaxation frequency. This work paves the way to on-chip implementation of Brownian magnetorelaxometry in innovative “lab-on-a-bead” assays for biomolecular recognition.
On-chip measurement of the Brownian relaxation frequency of magnetic beads using magnetic tunneling junctions
DONOLATO, MARCO;CANTONI, MATTEO;PETTI, DANIELA;BERTACCO, RICCARDO
2011-01-01
Abstract
We demonstrate the detection of the Brownian relaxation frequency of 250 nm diameter magnetic beads using a lab-on-chip platform based on current lines for exciting the beads with alternating magnetic fields and highly sensitive magnetic tunnel junction MTJ sensors with a superparamagnetic free layer. The first harmonic out-of-phase component of the MTJ response gives the imaginary part of the magnetic bead susceptibility, which peaks at the Brownian relaxation frequency. This work paves the way to on-chip implementation of Brownian magnetorelaxometry in innovative “lab-on-a-bead” assays for biomolecular recognition.File in questo prodotto:
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brownian relaxometry APL_98_073702_2011.pdf
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