When bound to residues which can work as particularly strong electron withdrawing groups, fluorine can display a region of positive electrostatic potential (positive sigma-hole). Fluorine can thus function as a halogen bond donor and form complexes with lone-pair-containing neutral atoms and anions. Examples in the gas, liquid, and solid phases are discussed.
The fluorine atom as a halogen bond donor, viz. a positive site
METRANGOLO, PIERANGELO;PILATI, TULLIO MARIA;RESNATI, GIUSEPPE;TERRANEO, GIANCARLO
2011-01-01
Abstract
When bound to residues which can work as particularly strong electron withdrawing groups, fluorine can display a region of positive electrostatic potential (positive sigma-hole). Fluorine can thus function as a halogen bond donor and form complexes with lone-pair-containing neutral atoms and anions. Examples in the gas, liquid, and solid phases are discussed.File in questo prodotto:
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